Antimicrobial, Structural, Optical, and Redox Profiling of 7<i>H</i>‑Benzo[<i>c</i>]carbazol-10-ol Derivatives: An Integrated Experimental and Computational Study.

ABSTRACT: Carbazoles represent a versatile class of heterocycles with wide-ranging applications in medicinal and materials chemistry. However, their functionalized derivatives remain underexplored, largely due to challenges in synthesis and derivatization. This study investigates, for the first time, the integrated antimicrobial, photophysical, and redox properties of structurally novel 7H-benzo-[c]-carbazol-10-ol derivatives. These derivatives, distinct from parent carbazoles, were synthesized via a one-pot annulation and C-C coupling approach, enabling access to hydroxylated and naphthyl-substituted scaffolds with enhanced bioactivity and optoelectronic features. The target compounds were initially screened for their in vitro antimicrobial activity using the agar well diffusio

SUBMITTER: Salem MSH 

PROVIDER: S-EPMC12771225 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature