Bone Metastatic Progression of Prostate Cancer Is Regulated by TRIM28-LDHA-Mediated Metabolism.

ABSTRACT: Castration-resistant prostate cancer, an advanced stage of prostate cancer, often leads to fatal bone metastasis. The vast majority of patients with prostate cancer who present with bone metastases suffer from bone lesions and other complications. Androgen receptor inhibitors, although improved, lack curative efficacy, necessitating an urgent demand for the development of innovative therapeutic strategies. TRIM28, also known as Krüppel-associated box-associated protein 1, is a transcription factor regulated by site-specific phosphorylation. Our recent study demonstrated that p90 ribosomal S6 kinase 1 is the protein kinase that directly phosphorylates TRIM28 at S473; as such, pS473-TRIM28 promotes the transcriptional activation of its gene targets. In this study, we reveal that TRIM28-S473

SUBMITTER: Kim M 

PROVIDER: S-EPMC12771278 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature