Beyond pain presence: the impact of multisite pain and pain interference on cognitive functioning among middle-aged and older adults.

ABSTRACT:

Objectives

This study investigates the relationship between chronic pain and cognitive function in the U.S. middle-aged and older population, focusing on the impact of the number of pain sites. It also explores whether pain interference mediates the association between pain sites and cognition.

Methods

Data were drawn from the 2004-2006 and 2013-2017 waves of the Midlife in the United States Study (MIDUS 2 and MIDUS 3, N = 2,219). We fit inverse-probability-weighted models to examine the associations between pain status, number of pain sites (none vs. 1-2 vs. 3+ sites), and cognitive function in MIDUS 3, controlling for confounders from MIDUS 2. The Sobel-Goodman mediation test with Bonferroni-adjusted significance level was applied to assess the mediating role of pain inter

SUBMITTER: Yu C 

PROVIDER: S-EPMC12771511 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature