Differential microRNA profiling of blood L1CAM and bulk extracellular vesicles in bipolar disorder.

ABSTRACT:

Objective

This preliminary study aimed to identify microRNA (miRNA) signatures associated with bipolar disorder (BD) by profiling blood-derived extracellular vesicles (EVs) of both putative neuronal origin and from all sources.

Method

In two parallel studies of individuals with BD and controls (CON), we characterized miRNA expression profiles of blood EVs selected for L1CAM, a putative marker of neuronal origin (n = 20 BD/20 CON), as well as bulk EVs (n = 21 BD/20 CON). For each study, analyses identified miRNAs differentially expressed between groups, followed by functional interrogation and testing for associations with clinical features.

Results

Results of Study 1 showed 34 miRNAs differentially expressed between groups and implicated PTEN, a gene who

SUBMITTER: Fries GR 

PROVIDER: S-EPMC12771548 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature