Integrating TERT promoter mutations into risk stratification of papillary thyroid cancer.

ABSTRACT:

Objective

The impact of telomerase reverse transcriptase (TERT) promoter mutations on short-term prognosis in papillary thyroid carcinoma (PTC) remains unclear. Clarifying this association may improve early risk stratification and guide timely management. This study aimed to evaluate the influence of TERT promoter mutations on short-term clinical outcomes in PTC and propose an enhanced risk stratification model incorporating TERT status.

Methods

This study analyzed 3,078 patients who underwent thyroidectomy for PTC at a tertiary referral center in South Korea from 2019 to 2021. Among these, 57 had TERT promoter mutations. Using propensity score matching (4:1) by age and sex, 227 patients with wild-type TERT promoter were selected. Short-term outcomes were categorized as no e

SUBMITTER: Yoo JH 

PROVIDER: S-EPMC12771558 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature