Longitudinal SARS-CoV-2 Antibody Response in Healthcare Workers: Benefit of Prior Infection and Heterologous Boosting on Anti-Spike IgG Immunity.

ABSTRACT:

Background and objectives

Different COVID-19 vaccine platforms elicit variable immune responses, influenced by prior infection and booster vaccination. We aimed to compare the humoral immune responses elicited by mRNA and adenoviral vector (Ad-vector) COVID-19 vaccines in hospital employees and to assess the possible impact of prior SARS-CoV-2 infection on these responses.

Methods

We performed a prospective observational cohort study by recruiting employees of the Universitair Ziekenhuis Brussel who were vaccinated with an mRNA or Ad-vector vaccine. We assessed anti-spike (S) IgG and neutralising capacity at 1, 6 and 12 months (post-mRNA booster). Anti-S and anti-NCP IgG were measured by chemiluminescent microparticle immunoassay, and neutralising capacity was assessed using

SUBMITTER: Van Nedervelde E 

PROVIDER: S-EPMC12771585 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature