Aesculus hippocastanum Extract Exerts Neuroprotective Effects in an MPP⁺-Induced Parkinson's Disease Model via PPARγ Activation.

ABSTRACT: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra. In this study, we investigated the neuroprotective and anti-inflammatory potential of Aesculus hippocastanum (horse chestnut extract, HCE) in an in vitro model of PD. Human neuroblastoma SH-SY5Y cells were treated with the neurotoxin 1-methyl-4-phenylpyridinium (MPP⁺) (1 mM) and/or in combination with HCE at the concentrations of 15.6, 31.2 and 62.5 μg/mL for 24 h. After 24 h, several analyses have been performed. Treatment with HCE at the concentrations of 31.2 and 62.5 μg/mL significantly improved cell viability following MPP⁺-induced neurotoxicity. Furthermore, HCE effectively modulated key Parkinsonian markers by restoring

SUBMITTER: Scuderi SA 

PROVIDER: S-EPMC12771594 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature