Randomized Study on Bilateral Versus Standard Mediastinal Lymphadenectomy in Patients With Lung Cancer-Early Results and Safety Analysis.

ABSTRACT:

Objectives

To evaluate whether bilateral mediastinal lymphadenectomy (BML) affects the feasibility and invasiveness of lung resection in patients with lung cancer and its associated risks of adverse effects (AE).

Methods

This multicentre randomized trial compared BML and systematic lymph node dissection (SLND). In all patients, standard anatomical lung resection was performed. In the BML group, the contralateral mediastinum was additionally dissected using the cervical approach.

Results

In total, 279 patients (135 BML and 144 SLND) were eligible for analysis; both groups had comparable basic clinical parameters. Both groups were comparable in terms of resection type (P = 0.193), blood loss (P = 0.927), and number of AE (P = 0.289). Compared with the SLND group, the BM

SUBMITTER: Kuzdzal J 

PROVIDER: S-EPMC12771642 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature