M⁶A modification mediates CACNA1A stability to drive the progression of ovarian cancer by inhibiting ferroptosis.

ABSTRACT: Ovarian cancer is a particularly lethal form of cancer affecting the female reproductive system. Prior research indicates a strong link between RNA epigenetic modification and the development of cancer. How different RNA modifications interact and affect cancer biological processes is not yet clearly understood. Our research using ovarian cancer tissue microarrays reveals that IGF2BP3, as crucial 'reader' of m⁶A, is considerably upregulated and correlated with negative clinical results. In vitro experiments IGF2BP3 stimulates the multiplication of ovarian cancer cells while inhibiting ferroptosis. Meanwhile, we identified firstly CACNA1A mediated by m⁶A modification as an innovative direct target of IGF2BP3 through RNA-Seq and MeRIP-seq and the m⁶A-modified

SUBMITTER: Gong X 

PROVIDER: S-EPMC12771733 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature