Prognostic implication of serum levels of IL-6 and IL-10 in children and adolescents with aggressive mature B-cell non-Hodgkin lymphoma.

ABSTRACT:

Background

Aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) is the most common subtype of non-Hodgkin lymphoma in children and adolescents. However, little progress has been made in determining the prognostic factors of children and adolescents with B-NHL. Based on the effect of cytokines in other cancer types, this study explored the effect of cytokines on the prognosis of children and adolescents with B-NHL.

Methods

The levels of serum cytokines including interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were detected at diagnosis. Correlations between cytokines, clinical characteristics, and treatment outcomes were retrospectively analyzed.

Results

In total, 139 patients aged < 18 years with newly diagnosed matu

SUBMITTER: Zeng C 

PROVIDER: S-EPMC12771761 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature