Global, regional, and national bladder cancer burden from 1990 to 2021 and forecasts to 2050: a systematic analysis of the global disease burden study in 2021.

ABSTRACT:

Background

Bladder cancer (BCa) remains a global health challenge, marked by geographic variations and evolving epidemiology. Despite new therapies, comprehensive assessments of long-term trends, risk factors, and predictive modeling are scarce. This study aimed to quantify the global, regional, and national burden of BCa in 2021, with stratification by age, sex, and geography. We further assessed temporal trends from 1990 to 2021 and projected future prevalence and mortality up to 2050. Finally, we analyzed demographic and regional disparities to identify high-risk populations and inform targeted prevention and resource allocation.

Methods

We utilized sex/age-stratified global registry data (29,377 sources) to model mortality via Bayesian spatiotemporal smoothing and incide

SUBMITTER: Feng W 

PROVIDER: S-EPMC12771838 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature