Fluid balance and mortality in adult ICU patients with sepsis or septic shock: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Background

Fluid therapy is a cornerstone of sepsis management; however, excessive fluid accumulation might be associated with adverse outcomes. The association between fluid balance (FB) and mortality in critically ill patients with sepsis or septic shock remains uncertain.

Methods

We conducted a systematic review and meta-analysis of observational studies assessing the association between FB and mortality in adult ICU patients with sepsis or septic shock (PubMed, Scopus, CINAHL; through May 2024). Random-effects models estimated pooled odds ratios (ORs) for all-cause mortality; meta-regression explored dose-response patterns and heterogeneity. Risk of bias was assessed with ROBINS-E; certainty of evidence with GRADE.

Results

Twenty-six studies(64,755 patients) were

SUBMITTER: Fonda F 

PROVIDER: S-EPMC12771878 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature