Effects of remimazolam versus propofol on the optic nerve sheath diameter in patients undergoing laparoscopic hysterectomy: a randomized controlled trial.

ABSTRACT:

Background

Previous studies have suggested that propofol can reduce intracranial pressure (ICP). However, the effects of remimazolam, a new intravenous anesthetic, on ICP remain unknown. This study aimed to compare the effects of remimazolam and propofol on the ICP in patients undergoing laparoscopic hysterectomy by measuring the optic nerve sheath diameter (ONSD) using ultrasound.

Methods

A total of 60 patients scheduled for elective laparoscopic hysterectomy were randomly assigned to remimazolam group (0.3 mg/kg induction, 1-2 mg/kg/h infusion) and propofol group (2 mg/kg induction, 4-8 mg/kg/h infusion). The ONSD was measured 5 min after induction of anesthesia in the supine position (T1); 15 min (T2), 30 min (T3), and 60 min (T4) following the establishment of pneumoperi

SUBMITTER: Ji H 

PROVIDER: S-EPMC12771910 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature