Donor-dependent heterogeneity in therapeutic effects of adipose tissue extracellular vesicles.

ABSTRACT:

Background

Extracellular vesicles (EVs) are promising therapeutics for diseases associated with inflammation and tissue remodeling. However, a major limitation for the clinical translation of EV therapeutics is heterogeneity, which is donor dependent. In this study we sought to assess the physiochemical characteristics and therapeutic efficacy of tissue-derived EVs from different donors. Donor-dependent therapeutic effects of cell culture and biofluid-derived EVs have previously been shown, but remains largely unknown for tissue-derived EVs. We obtained EV-enriched samples from various sources of adipose tissue and examined their effect in reducing inflammation in a highly translational model of myocarditis.

Results

We demonstrate that the molecular composition of EVs varies

SUBMITTER: Beetler DJ 

PROVIDER: S-EPMC12771929 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature