E2F7 promotes ESCC progression and cisplatin resistance through transcriptional activation of DVL3 and the Wnt signaling pathway.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis. While the transcription factor E2F7 has been implicated in cancer development, its specific role in ESCC and its association with cisplatin resistance remain unclear. This study aimed to investigate the expression, function, and underlying mechanism of E2F7 in ESCC progression and cisplatin resistance.

Methods

E2F7 expression was examined in ESCC tissues and cell lines using qRT-PCR, and its clinical significance was assessed through survival analysis. Functional roles of E2F7 were evaluated through cell proliferation, migration, and invasion assays. Mechanistic studies included dual-luciferase reporter assays and gene expression analyses to assess E2F7's regulation of

SUBMITTER: Li X 

PROVIDER: S-EPMC12771932 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature