From autoimmune inflammation to malignancy: causal genetic evidence for the RA-squamous cell lung cancer axis.

ABSTRACT:

Background

The association between rheumatoid arthritis (RA) and lung cancer risk has attracted considerable clinical attention, but conclusions remain inconsistent due to confounding factors such as smoking, and previous studies have paid less attention to specific histological subtypes. This study aims to systematically elucidate the complex relationship between the two through an evidence triangulation strategy combining large-scale clinical cohort studies, machine learning risk prediction, and genetic causal inference.

Methods

This study adopted an evidence triangulation strategy, integrating evidence from different populations and methods. First layer of evidence (clinical association, Chinese population): We conducted 1:1 propensity score matching analysis on a real-wo

SUBMITTER: Li J 

PROVIDER: S-EPMC12771934 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature