Metabolomic analysis of the endometrium of Large White and Meishan pigs reveals differences in biological processes during late gestation.

ABSTRACT:

Background

In pigs, genetic progress has led to an increase in perinatal mortality, mainly due to reduced piglet maturity. The end of gestation (90-110 days of gestation) plays a decisive role in the acquisition of fetal maturity. The endometrium is crucial for its acquisition as it provides nutrients to the fetus through the placenta. The aim of this study is to describe part of the metabolism of the endometrium in late pregnancy and in relation with neonatal survival. For this purpose, we performed untargeted metabolomic measurements by 1H nuclear magnetic resonance and gas chromatography coupled to a flame-ionization detector on 224 endometrial samples and compared the two days of the end of gestation (D90-D110, term at 114 days) and two maternal breeds with contrasted birth sur

SUBMITTER: Bonnet A 

PROVIDER: S-EPMC12771944 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature