Baseline Serum Vitamin C Levels in Pediatric Sepsis: Hazard of Mortality and Organ Dysfunction in a Single-Center Prospective Cohort.

ABSTRACT:

Objectives

To explore whether baseline serum vitamin C levels are associated with 28-day mortality and organ dysfunction in pediatric sepsis.

Design

Single-center, prospective cohort, 2021 to 2023.

Setting

Tertiary children's hospital PICU in China.

Patients

Patients 18 years old or younger with suspected infection and organ dysfunction.

Interventions

None.

Measurements and main results

Serum vitamin C concentrations were measured in 141 patients within 24 hours of PICU admission. The median (interquartile range) vitamin C level was 4.3 μg/mL (2.5-7.2). Patients were categorized into quartiles (Q) and the primary endpoint was 28-day mortality; the secondary endpoint was the pediatric Sequential Organ Failure Assessment (pSOFA) score on day 1. Over

SUBMITTER: Cui W 

PROVIDER: S-EPMC12771965 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature