Joint association of body mass index, abdominal obesity, and triglyceride-glucose index with stroke risk: insights from the China health and retirement longitudinal study.

ABSTRACT:

Objective

Individuals who are obesity or abdominal obesity (AO) often develop insulin resistance. This study aims to explore the separate and combined effects of body mass index (BMI), AO [assessed by waist circumference (WC)], and triglyceride-glucose (TyG) index on the incidence risk of stroke.

Methods

We analyzed 8746 participants aged 45 years or older from the China Health and Retirement Longitudinal Study (CHARLS). The primary study outcome was stroke incidence. Cox proportional hazard models were applied to explore the association between the combination of BMI, AO, and TyG index with the risk of stroke.

Results

During a median follow-up of 9 years, 812 (9.28%) participants had occurred strokes. Restricted cubic splines curves revealed a significant linear rela

SUBMITTER: Huo G 

PROVIDER: S-EPMC12771985 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature