Risk factors for healthcare-associated infection and colonization of Serratia marcescens in neonates: a systematic review and meta-analysis.

ABSTRACT:

Background

Serratia marcescens (S. marcescens) is a gram-negative opportunistic pathogen causing healthcare-associated infections in neonatal intensive care units (NICUs), with mortality rates of 22.4%-58.0% and multi-drug complicating treatment. Fragmented evidence on risk factors limits infection prevention and control (IPC) strategies.

Methods

Following PRISMA guidelines, we searched PubMed, Web of Science, Wanfang, and CNKI databases from inception to April 25, 2025 for studies in English or Chinese, examining risk factors for S. marcescens infection or colonization in neonates. All reported risk factors were extracted, with those reported in ≥ 3 studies defined as primary outcomes, and those reported in two studies defined as secondary outcomes. Pooled odds ratios (ORs)

SUBMITTER: Hu YQ 

PROVIDER: S-EPMC12772029 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature