3D dynamic magnetic microfluidic chip for efficient plasma extracellular vesicle enrichment and machine learning-based multiparametric diagnosis of hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide, with early diagnosis critical for improving outcomes. Current diagnostic tools, including serum biomarkers and imaging techniques, exhibit limited sensitivity and specificity. Although extracellular vesicles (EVs) have emerged as a promising source of cancer biomarkers, their clinical utility is hampered by inefficient enrichment technologies.To overcome this limitation, a microfluidic platform was developed to enable rapid and efficient EV capture.

Results

The 3D DynaMag-EV capture chip was developed, integrating active and passive micromixing strategies for efficient capture of plasma-derived EVs. This platform employs tentacle-like magnetic particles conjugated wi

SUBMITTER: Xi X 

PROVIDER: S-EPMC12772050 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature