Cluster-randomized evaluation of neonatal intensive care unit quality improvement interventions in extremely preterm infants: secondary analysis of the INTACT trial.

ABSTRACT:

Background

The Improvement of Neonatal Intensive Care Unit (NICU) Practices and Team Approach Cluster-randomized Controlled Trial (INTACT) tested a multidisciplinary quality improvement (QI) program but did not show improved survival without neurodevelopmental impairment at 3 years among infants with very low birthweight. However, the program's potential effect on acute-phase outcomes in extremely preterm infants (< 28 weeks of gestation) warrants further evaluation. This secondary analysis aimed to assess the effect of the INTACT study's QI intervention based on participatory learning and action on acute morbidities during the NICU stay and outcomes at 3 years of age.

Methods

We performed a secondary analysis of data from the INTACT trial, a cluster-randomized controlled tr

SUBMITTER: Toyoshima K 

PROVIDER: S-EPMC12772115 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature