Proteomic Characterization of Bottlenose Dolphin (<i>Tursiops truncatus</i>) Urine.

ABSTRACT: Urinary proteins offer multifaceted insights into tissue repair, dysfunction, and renal health, with significant implications for both human and veterinary medicine. However, marine mammal medicine lacks comprehensive studies on urine protein composition. This study aimed to describe the urine proteome of wild common bottlenose dolphins (Tursiops truncatus) at two Gulf of Mexico sites (Sarasota Bay, FL, and Barataria Bay, LA) and to compare urine proteins by sex. Ten urine samples (Barataria Bay, LA: N = 6; Sarasota Bay, FL: N = 4) were analyzed by nano LC-MS/MS. Peptide spectral matching identified 1872 protein families across all individuals (FDR < 0.01). Cystatin 11 was notably present in males (median rank abundance: 8.1%) and absent in females (median: 0.0%), with

SUBMITTER: Cusick KN 

PROVIDER: S-EPMC12772130 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature