Exploring Biomarkers in Type 2 Diabetes Mellitus versus Normoglycemia Identified through High-Throughput Proteomics: A Systematic Review and Meta-Analysis.

ABSTRACT: Recent advances in proteomics have enabled the identification of early protein biomarkers and metabolic disturbances associated with type 2 diabetes (T2D), a major global health challenge. This systematic review and meta-analysis synthesize evidence from 27 studies comparing proteomic profiles of individuals with T2D and normoglycemic controls, selected from 2,422 initial records. The QUADOMICS assessment showed good methodological reporting for sample handling and proteomic analysis (>70% of studies), but over 60% lacked information on confounding clinical factors and biomarker validation. A qualitative synthesis focused on 85 recurrently reported proteins (≥8 studies), which showed strong interconnectivity and were involved in immune response, lipid-protein organization, detoxification,

SUBMITTER: Garcia-Curras J 

PROVIDER: S-EPMC12772132 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature