PIP₂ corrects an endothelial Piezo1 channelopathy.

ABSTRACT: Brain capillaries are sensors of neural activity. When a brain region is active, capillary endothelial cells (ECs) sense neuron-derived mediators and elicit a local increase in blood flow (functional hyperemia) to support the rise in metabolic needs. This hyperemic response involves a rapid electrical component and a slower chemical component that involves Gαq PCR (G_qPCR) activation by agonists released from neurons. The intravascular forces associated with hyperemia engage mechanosensitive Piezo1-mediated signaling that serves a mechano-feedback control function to facilitate the return of elevated blood flow to basal levels. Whether G_qPCR activity influences Piezo1 mechanosensitive signaling has not been explored, despite the potential significant implications of su

SUBMITTER: Hashad AM 

PROVIDER: S-EPMC12772150 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature