Synaptic integration and competition in the substantia nigra pars reticulata-An experimental and in silico analysis.

ABSTRACT: The substantia nigra pars reticulata (SNr) is a primary output for basal ganglia signaling. It plays an important role in the control of movement, integrating inputs from upstream structures in the basal ganglia, before sending organized projections to a range of targets in the midbrain, brainstem, and thalamus. Here, we present a detailed in silico model of the mouse SNr, including its major afferent inputs. The electrophysiological and morphological properties of SNr neurons are characterized in acute brain slices via whole cell patch-clamp recordings and morphological reconstruction. Using reconstructed morphologies, multicompartmental models of single neurons are instantiated within the NEURON simulation environment and populated with relevant modeled ion channels. Model parameters are

SUBMITTER: Thompson WS 

PROVIDER: S-EPMC12772157 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature