Serological evaluation of coronavirus IgA and IgG antibodies in a repeated cross-sectional cohort of unvaccinated and vaccinated pregnant individuals over three months following SARS-CoV-2 infection.

ABSTRACT: Antibody surveillance provided valuable public health insights during the Coronavirus Disease 2019 (COVID-19) pandemic. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, vaccination, and cross-reactive responses from endemic coronaviruses (human coronaviruses [HCoVs]) can influence SARS-CoV-2 antibody responses, impacting reliability and interpretation of serological findings. Here, we investigated population-level SARS-CoV-2 and HCoV IgA and IgG responses following SARS-CoV-2 infection among unvaccinated and vaccinated pregnant individuals over 3 months. Using residual sera from routine antenatal screening of pregnant individuals in British Columbia between March 2020 to May 2022, we designed a retrospective repeated cross-sectional cohort of infected individuals eit

SUBMITTER: Tanunliong G 

PROVIDER: S-EPMC12772236 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature