Clonal outbreak of an extensively drug-resistant NDM-1 producing <i>Pseudomonas aeruginosa</i> in a local hospital in the Czech Republic.

ABSTRACT: A clonal outbreak of 18 ST773 NDM-1 producing Pseudomonas aeruginosa strains has been detected for the first time in the Czech Republic. The strains were extremely drug-resistant (XDR) and resistant to serum killing. SNP-based phylogeny and CRISPR assay typing showed minimal genomic variations among the isolates. The results suggest a high-risk, persistent, virulent clone causing the hospital outbreak, with the possibility of a nationwide outbreak.IMPORTANCEOur research on the novel detection of the NDM-1 gene in carbapenem-resistant Pseudomonas aeruginosa ST773 in the Czech Republic is of great significance for public health and infection control. Until now, the emergence of this gene in P. aeruginosa strains was uncommon in this region, as carbapenem resistance was p

SUBMITTER: Chudejova K 

PROVIDER: S-EPMC12772245 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature