Diagnostic performance of upper airway sampling sites for SARS-CoV-2 and influenza testing.

ABSTRACT: Early diagnosis of upper respiratory infections is essential to control infectious disease transmission within the community and to initiate relevant antiviral treatments. Nonetheless, variable sensitivities of sampling sites are often overlooked. We conducted a clinical trial at a COVID-19 outpatient test center, where healthcare workers collected nasopharyngeal, throat, nasal swabs, and saliva specimens. Each specimen was tested by RT-PCR for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza virus A and B, and respiratory syncytial virus (RSV). Clinical information was collected at enrollment and again 13 months later using an online questionnaire. From 4 March to 31 March 2023, 253 individuals were enrolled. Data from 250 participants were included in the analysis.

SUBMITTER: Lopez-Perez M 

PROVIDER: S-EPMC12772246 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature