The CpxR response regulator mediates the virulence of <i>Klebsiella pneumoniae</i> by regulating the expression of virulence-associated genes.

ABSTRACT: Klebsiella pneumoniae is a prominent human pathogen that has developed resistance to multiple antibiotics. While the roles of capsules and siderophores are well established, the identification of additional virulence determinants remains limited. In this study, we hypothesize that the two-component system response regulator CpxR is integral to the regulation of K. pneumoniae virulence via control of specific virulence-associated genes. The deletion of the cpxR gene resulted in reduced serum resistance and attenuated virulence in both Galleria mellonella larvae and murine infection models compared to the wild-type strain. To elucidate the repertoire of virulence-associated genes regulated by CpxR, a multidisciplinary workflow was employed, integrating RNA sequenc

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12772254 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature