Prebiotics as adjunctive treatment ameliorates DSS-induced colitis and gut microbiota.

ABSTRACT: The disturbance of gut microbiota is closely related to the occurrence and development of inflammatory bowel disease (IBD), which can be improved by the supplementation of prebiotics. The therapeutic benefits of exclusive enteral nutrition (EEN) on patients with IBD are variable, and it has adverse effects on gut microbiota. Therefore, it is necessary to explore the efficacy of EEN combined with prebiotics on colitis and gut microbiota. In our study, mice were administered distilled water containing 4% dextran sodium sulfate (DSS) to induce colitis, then fed with normal water, EEN, EEN combined with isomaltooligosaccharide (IMO), EEN combined with fructo-oligosaccharide (FOS), and EEN combined with polydextrose (POL) for 1 week, respectively. The results revealed that EEN combined with pre

SUBMITTER: Kong Y 

PROVIDER: S-EPMC12772285 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature