<i>Prevotella copri</i> facilitates wound healing in mice through the sphingosine-CerS1-ceramide metabolic pathway.

ABSTRACT: Skin wound repair constitutes a sophisticated biological process involving spatiotemporally coordinated molecular cascades, with emerging evidence highlighting the dynamic regulatory role of skin microbiota. Utilizing a broad-spectrum antibiotic (ABX)-treated murine model, we identified Prevotella copri as a core functional commensal in the wound microecosystem that orchestrates tissue regeneration through metabolite-host crosstalk. ABX-induced microbial remodeling significantly enriched P. copri relative abundance, accelerated wound closure, and upregulated pro-regenerative factors vascular endothelial growth factor and epidermal growth factor. Metabolomic profiling revealed that P. copri-secreted sphingosine undergoes bioconversion to C18-ceramide via the non-canonic

SUBMITTER: Zhao M 

PROVIDER: S-EPMC12772305 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature