Impact of carbapenem-resistant <i>Klebsiella pneumoniae</i> infection on gut microbiota and host immunity: a case-control study.

ABSTRACT: Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a critical global health threat with limited treatment options. While the gut microbiota is a reservoir for opportunistic pathogens and a regulator of host immunity, the reciprocal impact of systemic CRKP infection on gut microbial ecology and immune responses remains poorly defined. In a prospective case-control study, 38 patients with confirmed CRKP infection and 38 matched hospitalized controls without CRKP were enrolled. Fecal samples underwent 16S rRNA gene sequencing to characterize microbial profiles, and serum cytokine levels were quantified using multiplex immunoassays. CRKP infection was associated with significantly reduced microbial diversity and a distinct shift in community structure, characterized by depleti

SUBMITTER: Ding W 

PROVIDER: S-EPMC12772321 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature