A GntR family regulator HutC senses PCA to regulate histidine catabolism in <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Pathogenic bacteria, Pseudomonas aeruginosa, have evolved various regulatory mechanisms to cope with the adverse environments. HutC is associated with the regulation of histidine metabolism in bacteria. Despite extensive research on histidine metabolism, the identification of the HutC regulon is not systematic or comprehensive. In this study, we demonstrated that the hut operon including hutFCHUIG is involved in histidine catabolism in P. aeruginosa. We also identified that HutC participates in the regulation of histidine catabolism. Promoter activity measurement uncovered that HutC directly binds to the hutFHUIG promoter region and represses its transcription. Electrophoretic mobility shift assay with recombinant HutC showed that HutC directly represses

SUBMITTER: Cui G 

PROVIDER: S-EPMC12772324 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature