The expansion of culturable opportunistic pathogens and antibiotic resistance in mouse gut following antibiotic exposure.

ABSTRACT: Antibiotics significantly change gut microbiota, leading to dysbiosis and changes in bacterial community composition, which further results in a series of dysfunctions with severe health consequences. This work employed both culture-dependent and -independent methods to examine antibiotic-induced changes in gut microbiota at higher resolution using mouse models. By following bacterial changes and antibiotic resistance daily before antibiotic exposure, after antibiotic exposure, and during recovery, several significant novel findings were made. Ampicillin (AMP) and imipenem (IPM) treatment led to an acute, exponential, but temporary bloom in absolute abundances of live opportunistic pathogens Enterobacteriaceae and Enterococcus, while not affecting potentially beneficial Lactobaci

SUBMITTER: Wang B 

PROVIDER: S-EPMC12772332 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature