Syndromic molecular testing in mechanically ventilated patients with severe pneumonia: a supportive diagnostic approach.

ABSTRACT: Rapid identification of pathogens is critical in severe pneumonia patients for timely therapy in mechanically ventilated intensive care unit patients. Conventional diagnostics are time-consuming. The Allplex Respiratory Panels 1-4 detect 16 viruses and seven bacteria and provide faster results; however, because this molecular assay does not yield viable organisms, antimicrobial susceptibility testing cannot be performed. We compared conventional diagnostics with commercial panels to evaluate diagnostic performance and clinical utility. In this prospective study, a total of 30 bronchoalveolar lavage fluids and 80 tracheal aspirates were obtained from 110 unique ICU patients with severe pneumonia (January 2014 and April 2016). Conventional diagnostics were performed during illness, whereas t

SUBMITTER: Ursic T 

PROVIDER: S-EPMC12772339 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature