Global epidemiological and genetic characteristics of carbapenem-resistant <i>Escherichia coli</i> carrying <i>bla</i>_IMP.

ABSTRACT: Carbapenem-resistant Escherichia coli (CREC) is a serious global health threat. While bla_NDM-positive and bla_KPC-positive CRECs are well-characterized, the genomic and epidemiological features of bla_IMP-positive CRECs remain poorly understood. This study provides a comprehensive analysis of bla_IMP-positive CRECs by integrating local and global surveillance data. We characterized nine bla_IMP-4-positive CRECs from 94 CRECs collected from four tertiary hospitals in Zhejiang, China (2017-2024), using whole-genome sequencing and assays for antimicrobial susceptibility, plasmid transfer, stability, and fitness. The nine isolates were multidrug-resistant but susceptible to colistin, tigecycline, and a

SUBMITTER: Hu Y 

PROVIDER: S-EPMC12772345 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature