Deciphering strain differences in codY regulation of <i>Clostridioides difficile</i>s sporulation.

ABSTRACT: Clostridioides difficile is an anaerobic, spore-forming pathogen that causes diarrhea, colitis, and even death. C. difficile grows and replicates in the intestine as a vegetative bacillus, but must transition into a dormant spore to survive and transmit in the environment. The transformation into a spore is a complex developmental process that is regulated in response to conditions within the host, most notably nutrient limitation. Nutrient availability is sensed by C. difficile through transcriptional regulators, such as CodY. CodY is a global nutritional gene regulator that controls gene expression in response to branched-chain amino acids (BCAAs) and guanosine-triphosphate (GTP). It was previously observed that CodY represses C. difficile sporulation, but the

SUBMITTER: Monteiro MP 

PROVIDER: S-EPMC12772354 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature