Phenotypic and genotypic differences between bloodstream and non-blood <i>Candida krusei</i> isolates: implications for invasiveness and antifungal susceptibility.

ABSTRACT: Candida krusei is an opportunistic pathogen with intrinsic resistance to fluconazole. This study analyzed 174 C. krusei isolates from bloodstream infections (BSI, n = 115) and non-blood sources (n = 59). Biochemical profiling using the VITEK 2 YST ID Card revealed a significant difference in the TyrA reaction between BSI and non-blood isolates (P < 0.05). Antifungal susceptibility testing via CLSI broth microdilution and Sensititre YeastOne showed that BSI isolates were more susceptible to echinocandins and azoles than non-blood strains, with minor MIC discrepancies between methods. Microsatellite genotyping at eight loci demonstrated high genetic diversity. Notably, a cluster of respiratory isolates from COVID-19 patients suggested potential nosoc

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12772365 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature