Kidney-Derived ECM Hydrogels as Cell Delivery Devices.

ABSTRACT: Chronic kidney disease (CKD) represents a significant global health challenge, as emphasized by its increasing prevalence and limited treatment options. Stem cell-based therapies are promising alternatives for CKD treatment. In particular, adipose-derived mesenchymal stem cells (ASCs) have emerged as an attractive candidate cell source. However, challenges in optimizing stem cell delivery and survival upon implantation persist. The inclusion of stem cells in hydrogels addresses these challenges by providing mechanical support coupled to bioactive cues essential for kidney regeneration. In particular, hydrogels derived from a decellularized kidney extracellular matrix (dKECM) offer a biomimetic platform rich in native and important renal components. Herein, we investigate the performance of

SUBMITTER: Rodrigues AM 

PROVIDER: S-EPMC12772458 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature