Mortality risk prediction of uric acid to high-density lipoprotein cholesterol ratio in community residents: a cohort study.

ABSTRACT:

Background

The serum uric acid to high-density lipoprotein cholesterol ratio (UHR) is a marker reflecting systemic inflammation and metabolic dysregulation. This study aimed to explore the association of UHR with all-cause and cause-specific mortality in a community-based Chinese cohort.

Methods

This study included 9448 participants from the community-based prospective cohort study conducted in Pudong New Area, Shanghai, China. We employed Cox proportional hazards regression to assess the associations between UHR quartiles and mortality risks. Nonlinear trends were examined through restricted cubic spline Cox regression, while bivariate exposure-response surface plots showed the joint effects of UHR and age. Model performance improvements were evaluated using C-index changes

SUBMITTER: Ke J 

PROVIDER: S-EPMC12772544 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature