Synchrony between brain age and internalising and externalising symptoms across adolescence.

ABSTRACT:

Background

Adolescence is a period of rapid neurobiological and behavioural change, yet it remains unclear how deviations from normative brain maturation relate to the development of internalising and externalising symptoms.

Methods

Using data from the Adolescent Brain Cognitive Development (ABCD) Study, we combined brain age prediction with bivariate latent growth curve (BLGC) models to test whether deviations in brain maturation - indexed by the brain age gap (BAG) - relate to mental health development across late childhood and adolescence. Brain age was estimated using T1-weighted, diffusion (dMRI), resting-state fMRI, and multimodal MRI data across four waves (ages ~8.3-17.5). Internalising and externalising symptoms were assessed across ten waves with the self-report Br

SUBMITTER: Beck D 

PROVIDER: S-EPMC12772674 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature