Quantitative histopathological analysis of thrombi retrieved by mechanical thrombectomy and their association with stroke aetiology.

ABSTRACT:

Background and purpose

Approximately 25% of acute large vessel occlusive (LVO) ischaemic strokes are of unknown thrombotic origin, and there is a need to establish the aetiology to guide subsequent preventative measures. The aim of this study was to quantify thrombus composition in patients with LVO and explore associations between thrombus composition and stroke aetiology.

Methods

Thrombi were extracted from 132 patients with acute ischaemic stroke. Erythrocytes, leucocytes and F+P (fibrin+platelet) proportions were assessed in tissue sections stained with H&E, while CD3⁺ T cells and neutrophil extracellular traps (NETs) were quantified in immunohistochemistry-stained sections. Thrombus components, clinical parameters and interventional variables were compared be

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC12772974 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature