Protocatechuic acid attenuated inflammation caused by <i>Prevotella copri</i> and its metabolites.

ABSTRACT: Gut microbiota has been considered as a key bridge between phytochemicals and host immunity. Prevotella copri (P. copri) showed a close correlation with inflammation, and protocatechuic acid (PCA) has potential protective effects in our previous studies. To understand the underlying mechanism, a total of 108 healthy Duroc × Landrace × Yorkshire weaned piglets, aged 21 d, were randomly assigned into 3 groups, with 6 replicates and 6 piglets per replicate. The piglets were fed a basal diet, a basal diet containing 1.0 × 10⁸ CFU/kg P. copri or 1.0 × 10⁸ CFU/kg P. copri +400 mg/kg PCA for 28 d. Results showed that P. copri decreased the final body weight and average daily gain (ADG), while increased the feed-to-gain ratio (F/G), with inc

SUBMITTER: Gong J 

PROVIDER: S-EPMC12773465 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature