<i>Lactococcus lactis</i> subsp. Cremoris reprograms systemic metabolism and protects against myocardial injury.

ABSTRACT: Therapeutic microbes are increasingly recognized as potent modulators of host physiology, yet their influence beyond the gut remains underexplored. While Lactococcus lactis subsp. Cremoris (LLC) has been shown to preserve gut epithelial integrity and counteract Western diet-induced metabolic syndrome in murine models, its effects on extraintestinal systems such as the gut-cardiovascular axis, are not well defined. In this study, we employed a multimodal experimental approach to investigate whether LLC confers cardioprotective benefits. We showed that LLC supplementation significantly preserved cardiac function and reduced myocardial scarring following ischemia-reperfusion injury. Untargeted metabolomic profiling of cardiac tissue revealed distinct shifts in the cardiac metabolome, w

SUBMITTER: Gacasan CA 

PROVIDER: S-EPMC12773551 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature