Reduced Type-I Interferon by Plasmacytoid Dendritic Cells and Asthma in School-Aged Children.

ABSTRACT:

Background

Allergic sensitization and reduced ability to respond to viral infections may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells (pDC) are rare immune cells that produce type I interferons (IFN-I) and play a key role in orchestrating immune responses against viruses.

Objective

To further evaluate the function of pDC in children with asthma.

Methods

This study was based on a subset of 71 children from the Early Life Lung Function (ELLF) cohort at the age of 7 years. As part of the ELLF study, participants were characterized for atopic sensitization, viral infection history, and lung function testing. pDC responses to a TLR7/8 agonist were assessed in the presence or absence of anti-IgE using an in vitro

SUBMITTER: Coenen I 

PROVIDER: S-EPMC12773650 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature