Natural History of Airway Hyperresponsiveness and Its Association With Asthma Traits.

ABSTRACT:

Background

The natural history of airway hyperresponsiveness (AHR) from childhood to adulthood and its association with asthma status are poorly understood. We aim to define the natural history of AHR in relation to asthma characteristics such as symptoms, atopy and lung function to improve our understanding of the changes in AHR with asthma pathophysiology during adolescence.

Methods

Methacholine bronchial challenge test (BCT) was undertaken in the Isle of Wight whole population birth cohort at 10 years (n = 783), 18 years (n = 585) and 26 years (n = 86). Data on wheeze, lung function, and atopy were collected at each time point. Definite AHR was defined as methacholine concentration provoking a 20% decrease in Forced Expiratory Volume in 1 s (PC₂₀) at < 4 mg/mL.

SUBMITTER: Carra S 

PROVIDER: S-EPMC12773667 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature