Predictors of Response to Biologics for Severe Asthma: A Systematic Review and Meta-Analysis.

ABSTRACT: Biologics are effective for severe asthma, but not all patients benefit equally. There is an urgent need to understand which biologic works best for which patient. We systematically searched for predictors of response to biologics (except omalizumab) for severe asthma in four bibliographic databases and two trial registries from 1990 to 2024. Two reviewers screened records, extracted data, and assessed risk of bias using a modified CASP checklist. Data were synthesized narratively, and certainty of evidence assessed using the modified GRADE framework. Comparable studies were meta-analyzed using a random-effects model. From 5853 records, 21 studies were identified investigating predictors of anti-IL5/5Rα, 4Rα, and anti-TSLP response. We found predominantly 'moderate' to 'high' quality evide

SUBMITTER: Rattu A 

PROVIDER: S-EPMC12773690 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature