Prevalence and risk factors for nephrolithiasis in adults with cystic fibrosis: A retrospective cohort study.

ABSTRACT:

Background

Calcium oxalate nephrolithiasis is more common in persons living with cystic fibrosis (PwCF) than in the general population. A primary risk factor is exocrine pancreatic insufficiency (EPI) causing enteral hyperoxaluria. However, the relationship between nephrolithiasis and degree of EPI control has not been assessed.

Methods

A retrospective cohort study was conducted including all PwCF seen at our institution from 2018 to 2023 (n = 332). Collected data included socio-demographics, Charlson comorbidity index, EPI control status adjudicated by treating clinicians (classified as controlled, uncontrolled, or unknown), and nephrolithiasis events, which were classified as symptomatic or asymptomatic when nephrolithiasis were discovered incidentally on imaging. Incidenc

SUBMITTER: Ryoo DY 

PROVIDER: S-EPMC12773813 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature