Seizure Burden before and after Lidocaine as Add-On Therapy in (Amplitude-Integrated) Electroencephalography-Confirmed Neonatal Seizures.

ABSTRACT:

Introduction

The primary aim of this study was to evaluate the total seizure burden (TSB) and maximum hourly seizure burden (MSB) before and after the administration of lidocaine (LDC) as add-on therapy in neonates with amplitude-integrated electroencephalography (aEEG)-confirmed seizures. Secondary aims were documenting the need for additional ASM at 4, 12, and 24 h after LDC and the rate of seizure freedom for at least 24, 48, and 72 h after LDC.

Methods

This single-center, retrospective cohort study included neonates with persistent seizures after phenobarbital who received add-on LDC therapy. Neonates were monitored with a continuous 2-channel aEEG. The TSB and MSB were calculated using raw EEG data collected 4 h before and after the administration of LDC.

Results

SUBMITTER: Rondagh M 

PROVIDER: S-EPMC12774423 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature